2-STEP SYNTHESIS OF PYRIDO[2,3-D]PYRIMIDINES FROM ACYCLIC PRECURSORS - CYCLIZATION OF 2-CYANAMINO-4,6-DIPHENYLPYRIDINE-3-CARBONITRILE BY HYDROGEN HALIDES

Authors
VICTORY P CIRUJEDA J VIDALFERRAN A
Citation
P. Victory et al., 2-STEP SYNTHESIS OF PYRIDO[2,3-D]PYRIMIDINES FROM ACYCLIC PRECURSORS - CYCLIZATION OF 2-CYANAMINO-4,6-DIPHENYLPYRIDINE-3-CARBONITRILE BY HYDROGEN HALIDES, Tetrahedron, 51(37), 1995, pp. 10253-10258
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
37
Year of publication
1995
Pages
10253 - 10258
Database
ISI
SICI code
0040-4020(1995)51:37<10253:2SOPFA>2.0.ZU;2-O
Abstract
The cyclization of 2-cyanamino-4,6-diphenylpyridine-3-carbo promoted b y hydrogen halides takes place regiospecifically leading in all the ca ses to the 4-amino-2-halogen substituted pyrido[2,3-d]pyrimidine. This procedure completes a flexible and straightforward approach to aromat ic pyrido[2,3-d]pyrimidines from acyclic precursors.