CHARACTERIZATION OF BETA-CYCLODEXTRIN FOR DIRECT COMPRESSION TABLETING .2. THE ROLE OF MOISTURE IN THE COMPACTIBILITY OF BETA-CYCLODEXTRIN

The role of moisture in the compactibility of p-cyclodextrin has been examined. A physically modified beta-cyclodextrin (BCD-DC) was compare d to a commercial beta-cyclodextrin product (Kleptose(R)). The moistur e sorption-desorption isotherms of both beta-cyclodextrin samples show ed considerable hysteresis. This can be attributed to the fact that wa ter is associated to beta-cyclodextrin in the form of a crystal hydrat e. Both beta-cyclodextrin samples lost their compactibility on removal of water, thus demonstrating that moisture is essential for the compa ctibility of beta-cyclodextrin. A moisture content of about 14% appear s to be optimum for maximum compactibility of samples studied.