PROTEIN SPLICING - SELF-SPLICING OF GENETICALLY MOBILE ELEMENTS AT THE PROTEIN LEVEL

Authors
COOPER AA STEVENS TH
Citation
Aa. Cooper et Th. Stevens, PROTEIN SPLICING - SELF-SPLICING OF GENETICALLY MOBILE ELEMENTS AT THE PROTEIN LEVEL, Trends in biochemical sciences, 20(9), 1995, pp. 351-356
Citations number
33
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
20
Issue
9
Year of publication
1995
Pages
351 - 356
Database
ISI
SICI code
0968-0004(1995)20:9<351:PS-SOG>2.0.ZU;2-O
Abstract
Protein splicing is a newly discovered process that is the protein equ ivalent of RNA splicing. Protein splicing proceeds through a branched protein intermediate, and in vitro studies indicate that the reaction is autocatalytic, The excised 'intein' proteins are site-specific DNA endonucleases that catalyse genetic mobility of their DNA coding seque nce by an 'intein homing' mechanism.