LEFT-VENTRICULAR HYPERTROPHY AND LEFT ATR IA MORPHOLOGY IN NEVER TREATED ESSENTIAL-HYPERTENSION

The level of arterial pressure is not the sole determinant of cardiac and vascular adaptation to hypertension. In order to identify other fa ctors (such as preload) we categorized by echocardiography, 55 never t reated hypertensive patients and 39 age and gender-matched normal subj ects, according to values of relative wall thickness and left ventricu lar mass index. Normal left Ventricular anatomy was found in 63 % hype rtensives, whereas among hypertensives 7 % had ''concentric left ventr icular remodeling'', 16 % concentric left ventricular hypertrophy and 14 % had eccentric left ventricular hypertrophy. Systolic left atrial area (LA) was obtained from the four-chamber views. Mitral peak early diastolic (E) and late diastolic (A) flaw velocity was assessed by Dop pler. Because clinical characteristics such age and sex differed among the 5 groups only results of ANCOVA were reported (means +/- SD). [GR APHICS] We conclude that eccentric left ventricular hypertrophy may be associated with a parallel increase of left atrial area. Thus the ass ociation of an increase of cardiac volume in hypertensive patients wit h normal diastolic function suggest that volume overload may modulate the effect of arterial pressure on cardiac morphology.