Pr. Satish et As. Balasubramanian, THE NEUROTRANSMITTER RECEPTOR TRIAD - NICOTINIC ACETYLCHOLINE-RECEPTOR, GAMMA-AMINOBUTYRIC-ACID RECEPTOR (TYPE-A) AND INHIBITORY GLYCINE RECEPTOR, Current Science, 69(4), 1995, pp. 336-342
Many different neuroactive substances known as neurotransmitters, whic
h are involved in signal transduction, bind to specific membrane recep
tors in. the vertebrate central nervous system, Of particular interest
are the similarities shared by the nicotinic acetylcholine receptor,
gamma-aminobutyric acid receptor and inhibitory glycine receptor with
respect to their pentameric structure, their neurotransmitter binding
pockets, and colocalization with gephyrin. All three receptors undergo
phosphorylation catalysed by protein kinases A and C, The biochemical
defects in relation to these receptors result in the clinical manifes
tation of certain human disorders.