A CASE OF ALZHEIMERS-DISEASE WITH EXTENSIVE FOCAL WHITE-MATTER CHANGES

The case of a patient is reported who suffered from disturbed concentr ation and memory and constructive apraxia. She had only mild neuropsyc hological deficits at the first examination. T2-weighted MRI presented extensive focal white matter changes. A brain biopsy showed changes t ypical for Alzheimer's disease (AD). The extent of the white matter le sions was surprising compared to the mild clinical signs she had. This case confirms that AD may result in prominent white matter disease ca used by incomplete infarction or demyelination.