ENANTIOMER DISCRIMINATION BY CONTINUOUS PRECIPITATION

A continuous turbidimetric method for the discrimination of enantiomer s (L- and D-lysine) by the inhibitory action of L-lysine on the crysta llization of L-glutamic acid is proposed. A multidetection now system including an open-closed loop and a single detector permits the determ ination of kinetic parameters for the crystallization of L-glutamic ac id in the presence of 2-propanol. L-Lysine can thus be determined in t he presence of a 20 times higher D-lysine concentration. The proposed method was applied to the determination of L-lysine in pharmaceutical preparations with good results.