AN EXPEDIENT ENANTIOSELECTIVE SYNTHESIS OF N-T-BOC-PROTECTED PHENYLSARCOSINE

Authors
VOYER N ROBY J
Citation
N. Voyer et J. Roby, AN EXPEDIENT ENANTIOSELECTIVE SYNTHESIS OF N-T-BOC-PROTECTED PHENYLSARCOSINE, Tetrahedron letters, 36(37), 1995, pp. 6627-6630
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
37
Year of publication
1995
Pages
6627 - 6630
Database
ISI
SICI code
0040-4039(1995)36:37<6627:AEESON>2.0.ZU;2-S
Abstract
Herein we describe a novel approach to the asymmetric synthesis of N-t -Boc-phenylsarcosine. The synthesis involves the enantioselective depr otonation at the benzylic position of N-t-Boc-N-methylbenzylamine 2 us ing the chiral complex s-BuLi/(-) sparteine 1 followed by a stereosele ctive carboxylation.