TRICYCLIC OXADIAZAPHOSPHORINE OXIDE GUANOSINES - A NEW STRATEGY TO FUNCTIONALIZE GUANOSINE AT THE EXOCYCLIC AMINO GROUP

Authors
ROBIDOUX S GUO YK DAMHA MJ
Citation
S. Robidoux et al., TRICYCLIC OXADIAZAPHOSPHORINE OXIDE GUANOSINES - A NEW STRATEGY TO FUNCTIONALIZE GUANOSINE AT THE EXOCYCLIC AMINO GROUP, Tetrahedron letters, 36(37), 1995, pp. 6651-6654
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
37
Year of publication
1995
Pages
6651 - 6654
Database
ISI
SICI code
0040-4039(1995)36:37<6651:TOOG-A>2.0.ZU;2-T
Abstract
A simple procedure is described for the preparation of modified guanos ines via an oxadiazaphosphorine oxide guanosine derivative. This nucle oside has been successfuly used in the synthesis of guanosine containi ng -(CH2)(2)OH, -(CH2)(6)NH2, -NHNH2 ''handles'', or a tethered acridi ne moiety at the 2-position