AN ASYMMETRIC-SYNTHESIS OF A KEY INTERMEDIATE TO 1-BETA-METHYLCARBAPENEM ANTIBIOTICS

Authors
HANG SH LEE HS
Citation
Sh. Hang et Hs. Lee, AN ASYMMETRIC-SYNTHESIS OF A KEY INTERMEDIATE TO 1-BETA-METHYLCARBAPENEM ANTIBIOTICS, Tetrahedron letters, 36(37), 1995, pp. 6713-6716
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
37
Year of publication
1995
Pages
6713 - 6716
Database
ISI
SICI code
0040-4039(1995)36:37<6713:AAOAKI>2.0.ZU;2-Z
Abstract
1 beta-Methylcarbapenem 3 has been enantioselectively synthesized star ting from ethoxyethyl ether 8 and methyl (R)-3-iodo-2-methylpropionate via the intramolecular 1,3-dipolar cycloaddition of nitrone 6, in whi ch the requisite chiral centers were settled.