SYNTHESIS OF FRAGMENTS OF TRANSFORMING GROWTH-FACTOR-ALPHA INCORPORATING EXO-2-AZABICYCLO[2,2,1]HEPTANE-3-CARBOXYLIC ACIDS AS PROLINE SUBSTITUTES

Citation
Jm. Mellor et al., SYNTHESIS OF FRAGMENTS OF TRANSFORMING GROWTH-FACTOR-ALPHA INCORPORATING EXO-2-AZABICYCLO[2,2,1]HEPTANE-3-CARBOXYLIC ACIDS AS PROLINE SUBSTITUTES, Tetrahedron letters, 36(37), 1995, pp. 6765-6768
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404039
Volume
36
Issue
37
Year of publication
1995
Pages
6765 - 6768
Database
ISI
SICI code
0040-4039(1995)36:37<6765:SOFOTG>2.0.ZU;2-X
Abstract
Two novel amino acids, the enantiomers of exo 2-azabicyclo[2,2,1]hepta ne-3-carboxylic acid have ben independently synthesized by the aza Die ls Alder reaction using a chiral auxiliary. The two acids have been ad vanced via solid phase synthesis to afford linear sequences, which hav e been cyclized to afford cyclic disulfide peptides, analogues of frag ments of TGF alpha. The structures of these and other fragments have b een firmly established.