TOTAL SYNTHESIS OF 19(RS)-F-LTA(4) METHYL-ESTER

Authors
GARCIA M DURAND T GIRARD JP ROSSI JC SERKOV I KUKLEV D BEZUGLOV V
Citation
M. Garcia et al., TOTAL SYNTHESIS OF 19(RS)-F-LTA(4) METHYL-ESTER, Tetrahedron letters, 36(36), 1995, pp. 6437-6438
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
36
Year of publication
1995
Pages
6437 - 6438
Database
ISI
SICI code
0040-4039(1995)36:36<6437:TSO1M>2.0.ZU;2-B
Abstract
The first total synthesis of 19(RS)-fluoroleukotriene A(4) methyl este r 8 is presented. The strategy focuses on omega-1 functionalized phosp honium salt as (3(Z)-8-fluorononenyl)triphenyl phosphonium iodide 6 an d its coupling with epoxydienal 7.