ENZYMATIC ACCESS TO HOMOCHIRAL L-ACETOXY-2-HYDROXYCYCLOHEXANE-3,5-DIENE THROUGH LIPASE-ASSISTED ACETYLATION IN ORGANIC-SOLVENT

Authors
NICOLOSI G PATTI A PIATTELLI M SANFILIPPO C
Citation
G. Nicolosi et al., ENZYMATIC ACCESS TO HOMOCHIRAL L-ACETOXY-2-HYDROXYCYCLOHEXANE-3,5-DIENE THROUGH LIPASE-ASSISTED ACETYLATION IN ORGANIC-SOLVENT, Tetrahedron letters, 36(36), 1995, pp. 6545-6546
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
36
Year of publication
1995
Pages
6545 - 6546
Database
ISI
SICI code
0040-4039(1995)36:36<6545:EATHL>2.0.ZU;2-B
Abstract
Enantiotoposelective acetylation of cis-1,2-dihydroxycyclohexa-3,5-die ne with vinyl acetate in tert-butyl methyl ether, promoted by immobili zed lipase from Mucor miehei (Lipozyme(R) IM), afforded (1R,2S)-1-acet oxy-2-hydroxycyclohexa-3,5-diene in good chemical yield and high enant iomeric excess.