HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF IOBITRIDOL IN PLASMA, URINE AND BILE

Iobitridol is a new non-ionic, low-osmolality contrast medium for urog raphy and angiography. We have developed a method for determining iobi tridol in body fluids using high-performance liquid chromatography wit h ultraviolet detection. The method, which is specific and reproducibl e, does not require an internal standard. Determinations can be carrie d out in body fluids against a set of standards in ethanol. The method was validated for the quantification of iobitridol in biological samp les obtained during pharmacokinetic studies.