THE EFFECTS OF SPIRONOLACTONE ON TESTOSTERONE FRACTIONS AND SEX-HORMONE BINDING GLOBULIN BINDING-CAPACITY IN HIRSUTE WOMEN

This study explored the effect of the anti-androgen spironolactone on sex-hormone binding globulin (SHBG) and the distribution of circulatin g testosterone (T) into various free and bound fractions in seven wome n with hirsutism assessed before and then monthly for three months on a regimen of spironolactone, 100 mg bid as the sole therapeutic agent, Blood samples were taken at each assessment time for a battery of and rogen parameters and serum T fractions studies, None of the women were judged obese based upon body mass index values. After three months of spironolactone therapy, there was little change in the hirsutism inde x, and measurement of serum T, androstenedione, DHEA-S and 17 beta-est radiol showed no significant changes, the same occurring with SHBG-bin ding capacity. However, there was a shift in the distribution of circu lating T, with a decrease in SHBG-bound T and an increase in albumin-b ound and free T (non-SHBG-bound fractions). As previous reports sugges t that non-SHBG-bound fractions represent bioavailable fractions, the current data suggests that T fraction studies may not be clinically us eful parameters of hyperandrogenism in women receiving antiandrogen th erapy.