This study was initiated to investigate the incidence of acute mortali
ty from air embolism associated with perioperative blood recovery and
the causative factors and common characteristics of such fatalities. A
ll facilities providing transfusion services in New York State are req
uired to report severe adverse reactions to, and the total number of,
transfusion and blood recovery procedures performed. Relevant data for
the period from January 1990 to June 1995 were tabulated. During this
time, 127,586 perioperative blood recovery procedures were performed,
and 8,955,619 conventional blood components were transfused. The freq
uency of fatal air embolism after readministration of recovered blood
was approximately 1:30,000-1:38,000; none followed conventional transf
usion. Characteristics common to the fatalities (including an addition
al case reported before the study interval) were examined; all involve
d reinfusion of recovered blood under pressure. In the population stud
ied, the incidence of fatal air embolism af ter the perioperative read
ministration of recovered blood was significantly higher than that aft
er conventional transfusion. A model of such a system demonstrated tha
t as much as 200 mL of air could enter the circulation in as little as
4 s, rendering visual detection and intervention extremely difficult.
Education and guidelines to reduce the risk and mortality associated
with this procedure are recommended.