We derive the diffusion equation for a sphere immersed in an incompres
sible fluid in homogeneous flow, The effect of the finite size of the
sphere is taken into account. The generalized Green-Kubo formula and t
he Stokes-Einstein relation are derived. As special cases, we analyze
the diffusion coefficient for the cases of the simple shear flow and t
he pure rotational flow in detail. The relation between nonanalytic de
pendence on the velocity gradient and on the frequency is discussed.