THE QUANTITATIVE-ANALYSIS OF INHALATIONAL ANESTHETICS IN FORENSIC SAMPLES BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY SELECTED-ION MONITORING

Authors
MARUYAMA K TAKATSU A OBATA T
Citation
K. Maruyama et al., THE QUANTITATIVE-ANALYSIS OF INHALATIONAL ANESTHETICS IN FORENSIC SAMPLES BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY SELECTED-ION MONITORING, BMC. Biomedical chromatography, 9(4), 1995, pp. 179-182
Citations number
7
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy",Biology,"Biochemical Research Methods
Journal title
BMC. Biomedical chromatography → ACNP
ISSN journal
02693879
Volume
9
Issue
4
Year of publication
1995
Pages
179 - 182
Database
ISI
SICI code
0269-3879(1995)9:4<179:TQOIAI>2.0.ZU;2-A
Abstract
The quantitative analysis of volatile anaesthetics for biomedical appl ications by means of gas chromatography/mass spectrometry/selected ion monitoring (GC/MS/SIM) was studied, Xenon gas was selected as an inte rnal standard for the assay by adding to a closed system, because of i ts stability and inactivity, In the assay of inhalational anaesthetics , isoflurane and nitrous oxide (laughing gas), in forensic samples (se rum and cerebrospinal fluid), the calibration of the anaesthetic was l inear from 0.12 to 12 nmol/mL in isoflurane and from 30 to 300 nmol/mL in nitrous oxide. Our results suggest that this new method is suitabl e for the quantitative analysis of inhalational anaesthetics in the bi omedical field.