METABOTROPIC GLUTAMATE-RECEPTOR AGONIST TRANS-AZETIDINE-2,4-DICARBOXYLIC ACID FACILITATES MAINTENANCE OF LTP IN THE DENTATE GYRUS IN-VIVO

Authors
RIEDEL G MANAHANVAUGHAN D KOZIKOWSKI AP REYMANN KG
Citation
G. Riedel et al., METABOTROPIC GLUTAMATE-RECEPTOR AGONIST TRANS-AZETIDINE-2,4-DICARBOXYLIC ACID FACILITATES MAINTENANCE OF LTP IN THE DENTATE GYRUS IN-VIVO, Neuropharmacology, 34(8), 1995, pp. 1107-1109
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
34
Issue
8
Year of publication
1995
Pages
1107 - 1109
Database
ISI
SICI code
0028-3908(1995)34:8<1107:MGAT>2.0.ZU;2-U
Abstract
We examined the role of metabotropic glutamate receptors by studying t he effect of intracerebroventricular infusion of the putative mGluR ag onist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potent iation (LTP) in the dentate gyrus of freely moving rats. Weak tetaniza tion caused a decremental potentiation which returned to baseline leve ls within 2 hr. Injections of tADA (20 mM/5 mu 1) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.