2-YEAR FOLLOW-UP-STUDY OF A PATIENT WITH PARKINSONS-DISEASE AND SEVERE MOTOR FLUCTUATIONS TREATED BY COGRAFTS OF ADRENAL-MEDULLA AND PERIPHERAL-NERVE INTO BILATERAL CAUDATE NUCLEI - CASE-REPORT

WE PERFORMED CO-GRAFTS of adrenal medulla and peripheral nerve into th e bilateral caudate nuclei of a 43-year-old patient with advanced Park inson's disease who showed severe daily motor fluctuations before surg ery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant ame lioration of the parkinsonian symptoms starting 2 weeks after transpla ntation. The alleviation of akinesia during ''off'' periods was the mo st apparent clinical improvement and continued for 2 years after surge ry. The dosage of L-dopa/benserazide was significantly reduced after s urgery compared with that before surgery. The results indicate that co -grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.