THROMBOCYTOPENIA IN PATIENTS WITH LUPUS N EPHRITIS

60 patients with lupus nephritis (LN) were examined for frequency of t hrombocytopenia, role of IgG and IgM antibodies to cardiolipin (AC), a ntithrombocytic antibodies (AA) and anaerobic platelet metabolism. Thr ombocytopenia occurred in 28 (46.7%) patients, it was 2 times more fre quent in active LN patients with AC than in those free of AC. AA were recorded in 36.6% of patients (32.2% versus 37.5% for patients with th rombocytopenia and free: of it, respectively). In active LN platelet a ctivity and metabolism became enhanced. Genesis of thrombocytopenia in various LN forms maybe induced by different mechanisms.