USE OF INHIBITORS OF ANGIOTENSIN-CONVERTI NG ENZYME IN CHRONIC DIFFUSE RENAL DISEASES

The treatment with inhibitors of angiotensin-converting enzyme (ACE) w as conducted in 57 patients with chronic diffuse renal diseases. Of th em 45 patients received capoten, 12 patients renitek. ACE-inhibitors w ere examined for effects on arterial pressure, proteinuria, renal and intrarenal hemodynamics. A hypotensive effect was apparant in hyperten sion and minimal in normotension. One month later renal bloodflow incr eased, glomerular filtration rate did not change. ACE-inhibitors prove d able to correct intrarenal hypertension: renal functional reserve re turned to normal on posttreatment month 1-3 in 10 of 16 patients. Noti ceable antiproteinuria effect of the drugs emerged 3 months after the treatment.