TIME-COURSE CHANGES IN PROTEINURIA AND AR TERIAL-PRESSURE - SIGNIFICANCE FOR DETECTION OF LATE GESTOSIS IN PREGNANT-WOMEN WITH RENAL DISEASES AND ESSENTIAL-HYPERTENSION

Time course of 187 pregnancies was followed up in 103 females with chr onic renal diseases (CRD), 76 females with essential hypertension (EH) and 14 posteclampsism females. Three variants of arterial pressure (A P) and 5 types of proteinuria changes were recognized in CRD and EH pa tients. The pattern of these changes was compared to that in posteclam psism patients, tile eclampsism being an absolute criterium of late to xicosis. It is shown that neither elevated AP and proteinuria nor thei r absolute values can serve reliable signs of late gestosis in CRD and EH patients. Only the trend in these parameters is significant. CRD a nd EH females with late gestosis exhibit rapidly growing proteinuria i n line with the onset or exacerbation of EH. Retrospective analysis of the pregnancies has confirmed association of late gestosis in 15% of EH and 7% of chronic glomerulonephritis patients. These estimates are lower than commonly accepted. Early diagnosis of late gestosis in preg nant females with CRD and EH requires not only regular AP registration , but also dynamic, in some cases hourly, evaluation of proteinuria.