EFFICACY OF THE COMBINATION ERYTHROPOIETI N-CALCITRIOL IN PATIENTS WITH CHRONIC-RENAL-FAILURE ON PROGRAMMED HEMODIALYSIS

Time course of 187 pregnancies was followed up in 103 females with chr onic renal diseases (CRD), 76 females with essential hypertension (EH) and 14 posteclampsism females. Three variants of arterial pressure (A P) and 5 types of proteinuria changes were recognized in CRD and EH pa tients. The pattern of these changes was compared to that in posteclam psism patients, the eclampsism being an absolute criterium of late tox icosis. It is shown that neither elevated AP and proteinuria nor their absolute values can serve reliable signs of late gestosis in CRD and EH patients. Only the trend in these parameters is significant. CRD an d EH females with late gestosis exhibit rapidly growing proteinuria in line with the onset or exacerbation of EH. Retrospective analysis of the pregnancies has confirmed association of late gestosis in 15% of E H and 7% of chronic glomerulonephritis patients. These estimates are l ower than commonly accepted. Early diagnosis of late gestosis in pregn ant females with CRD and EH requires not only regular AP registration, but also dynamic, in some cases hourly, evaluation of proteinuria.