Tb. Prokaeva et al., DOES ANTIRHEUMATIC THERAPY INFLUENCE THE DEVELOPMENT OF SECONDARY AMYLOIDOSIS IN RHEUMATOID-ARTHRITIS, Terapevticeskij arhiv, 67(5), 1995, pp. 47-49
Anti-rheumatic drug treatments were studied in 260 patients from Finla
nd and Russia suffeiring from rheumatoid arthritis (RA) with or withou
t biopsy-proven secondary amyloidosis (RSA). Chloroquine was used for
longer period in RSA group in Russia (p = 0.003) and in Finland (p = 0
.06). In Finland chloroquine was used more often in tile RSA group (p
= 0. 02), and sulphasalazine (p = 0.02), D-penicillamine (p = 0.03) an
d cytotoxics (p = 0.04) in the control group. The role of therapy in t
he prevention of RSA in chronic inflammation is discussed.