OBJECTIVE: To determine the reproducibility and accuracy of the PAPNET
system in finding and presenting abnormal and atypical cells. STUDY D
ESIGN: To assess the potential variation of a double PAPNET scan on th
e same cervical smear, 516 cervical smears from women with abnormal hi
stologic diagnoses were scanned twice via PAPNET and reviewed by two i
ndependent examiners in a double-blind trial. RESULTS: The false negat
ive rate of 5.7% in conventional screening was reduced to 0.4% and 0.8
%, respectively, by PAPNET testing. The resulting concurrence of the f
irst and the second PAPNET reviews was 99.2%, indicating the accuracy,
sensitivity and consistency of this supplemental test. CONCLUSION: Th
e results obtained demonstrate the reproducibility and accuracy of the
system in finding and presenting abnormal and atypical cells.