Perceived, but not actual, control over treatment has been consistentl
y related to better adjustment in chronic illness. This study examined
the relationship between actual control over treatment and severity o
f illness and their influence on depression in a chronically iii popul
ation of end-stage renal disease (ESRD) patients. The authors hypothes
ized that as severity of illness increases, the burden of control over
treatment would increase depression. Severity of illness and depressi
on were assessed for 98 ESRD patients. Control over treatment was repr
esented by whether dialysis patients were self-administering treatment
(high control) or were receiving treatment from the medical staff(low
control). Results indicated that for the most severely ill patients,
high control over treatment resulted in poorer adjustment. Furthermore
, this effect was due in part to how illness interferes with social re
lationships in seriously ill, self-care patients.