Ma. Higham et al., DETERMINATION OF THE MINIMUM DOSE OF LACTOSE DRUG CARRIER THAT CAN BESENSED DURING INHALATION, British journal of clinical pharmacology, 40(3), 1995, pp. 281-282
Lactose is commonly used as a carrier for inhaled drugs. Twenty health
y volunteers without respiratory: symptoms inhaled seven different dos
es of. lactose and a placebo (empty) dose through the four place Diskh
aler(R) device, in order to determine the lowest dose that could be re
liably sensed. The minimum dose for which all subjects reported taste
or feel sensations was 10 mg. This has implications regarding the amou
nt of carrier used in future drug delivery systems.