CYCLOSERINE-INDUCED LICHENOID DRUG ERUPTION

A 65-year-old male patient who has taken antituberculous drugs includi ng cycloserine for 8 months showed multiple pruritic, violaceous, flat -topped papules and plaques on his back which had developed 5 months i nto therapy. Histopathologic findings were consistent with lichenoid d rug eruption. Patch test with the drugs revealed a strongly positive r eaction to cycloserine only. Four months after discontinuation of oral cycloserine, pruritus resolved and the lesions subsided without any n ew lesions. Cycloserine is one of the antituberculous drugs. Skin mani festations resulting from its administration are reported to be rare, but to our knowledge, this is the first case report of lichenoid drug eruption from its use.