Many theories have been advanced concerning the relationship between s
tructure and function in the human foot, yet few of these theories hav
e been subjected to quantitative examination. In this study, foot stru
cture was characterized by 27 measurements taken from standardized lat
eral and dorsi-plantar weight-bearing plain radiographs of 50 healthy
adult subjects. Regional plantar pressure distribution data collected
from the same feet were chosen as the functional measures. A stepwise
regression analysis was performed to (1) explore what portion of the v
ariance in peak plantar pressure during walking can be explained by th
e radiographic measurements, and (2) identify structural characteristi
cs of the foot which are significant predictors of peak plantar pressu
re under the heel and the first metatarsal head (MTH1). Most of the ra
diographic measurements were highly reliable. However, only 31 and 38%
of the variance in peak plantar pressure at the heel and MTH1, respec
tively, could be explained using multiple regression analyses with the
radiographic measurements as independent variables. Among the structu
ral predictors that were identified, soft tissue thickness (e.g. calca
neus or sesamoid heights), and arch-related measurements were the stro
ngest predictors of plantar pressure under both the heel and the first
metatarsal head. We conclude that, in normal subjects, only about 35%
of the variance in dynamic plantar pressure can be explained by the m
easurements of foot structure derived from radiographs. This implies t
hat the dynamics of gait are likely to exert the major influence on pl
antar pressure during walking. (C) 1997 Elsevier Science Ltd.