BIOTRANSFORMATION OF (-CEDROL BY PLANT-PATHOGENIC FUNGUS, GLOMERELLA-CINGULATA())

Microbial transformation of (+)-cedrol has been investigated by using plant pathogenic fungus, Glomerella cingulata. (+)-Cedrol was hydroxyl ated at the C-3 position, and transformed mainly to 3 alpha-hydroxyced rol and with a smaller amount of 3 beta-hydroxycedrol, 3 alpha-Hydroxy cedrol was further transformed to 8-cedren-3 alpha-ol by dehydration a t the C-8 position. In addition, G. cingulata produced a small amount of 12-hydroxycedrol from (+)-cedrol with stereoselective hydroxylation of the methyl group at the C-12 position. The structures of the metab olic products were determined by their spectroscopic data.