ANTIMALARIAL SESQUITERPENES FROM TUBERS OF CYPERUS-ROTUNDUS - STRUCTURE OF 10,12-PEROXYCALAMENENE, A SESQUITERPENE ENDOPEROXIDE

Authors
THEBTARANONTH C THEBTARANONTH Y WANAUPPATHAMKUL S YUTHAVONG Y
Citation
C. Thebtaranonth et al., ANTIMALARIAL SESQUITERPENES FROM TUBERS OF CYPERUS-ROTUNDUS - STRUCTURE OF 10,12-PEROXYCALAMENENE, A SESQUITERPENE ENDOPEROXIDE, Phytochemistry, 40(1), 1995, pp. 125-128
Citations number
22
Categorie Soggetti
Plant Sciences
Journal title
Phytochemistry → ACNP
ISSN journal
00319422
Volume
40
Issue
1
Year of publication
1995
Pages
125 - 128
Database
ISI
SICI code
0031-9422(1995)40:1<125:ASFTOC>2.0.ZU;2-K
Abstract
Activity-guided investigation of Cyperus rotundus tubers led to the is olation of patchoulenone, caryophyllene cc-oxide, 10,12-peroxycalamene ne and 4,7-dimethyl-1-tetralone. The antimalarial activities of these compounds are in the range of EC(50) 10(-4)-10(-6) M, with the novel e ndoperoxide sesquiterpene, 10,12-peroxycalamenene,exhibiting the stron gest effect at EC(50) 2.33 x 10(-6) M.