Two new carbazole alkaloids, designated as clausenol and clausenine, w
ere isolated from an alcoholic extract of the stem bark of Clausena an
isata. Their structures were established as 1-hydroxy-6-methoxy-3-meth
ylcarbazole and 1,6-dimethoxy-3-methyl carbazole, respectively, from p
hysical and chemical evidence and synthesis. Clausenol was found to be
active against Gram-positive and Gram-negative bacteria and fungi.