EFFECT OF A COMBINATION OF PENTOXIFYLLINE AND NIMODIPINE ON LIPID-PEROXIDATION IN POSTISCHEMIC RAT-BRAIN

The authors studied the effects of a combination of pentoxifylline and nimodipine on cerebral lipid peroxidation in postischemic rat brain. Pentoxifylline (40 mg/kg) and nimodipine (3 mg/kg) were administered p er os 30 min before 5 min of ischemia (four-vessel occlusion model of transient ischemia). The extent of peroxidation in brain tissue (cereb ral cortex, hippocampus, striatum) was then estimated by-assay of thio barbituric acid reactive substances (TEARS). The concentration of TEAR S was significantly lower in the cerebral cortex and hippocampus of th e group treated with the combination of drugs than in untreated ischem ic rats. However, this concentration was not significantly different f rom that found in the cerebral cortex and hippocampus of other groups premedicated with nimodipine or pentoxifylline alone.;The tested drugs had no effect on TEARS in the striatum. The hypothesis that the combi nation of drugs would have a synergistic effect on postischemic lipid peroxidation was therefore not confirmed.