SHORT-TERM POSTISCHEMIC HYPOPERFUSION IMPROVES RECOVERY OF PROTEIN-SYNTHESIS IN THE RAT-BRAIN CORTEX

A cell-free system from rat brain cortex was used to follow changes in protein synthesis after ischemia and reperfusion (four-vessel occlusi on). The experiment was focused to prevent a violent burst of free oxy gen radicals creation during the first period of postischemic reperfus ion by short-Germ hypoperfusion. After 30 min of ischemia, the authors applied hypoperfusion produced by releasing one (right) carotid for t he first 5 min of reperfusion lasting from 30 min to 3 d. Results obta ined by this procedure show that the activity of protein synthesis mac hinery from hypoperfused brains is higher than normovolemic ones; the left hemisphere, which is contralateral to direct blood flow during hy poperfusion, shows better results than the right hemisphere.