Tissue tagging using magnetic resonance (MR) imaging has enabled quant
itative noninvasive analysis of motion and deformation in vivo. One me
thod for MR tissue tagging is Spatial Modulation of Magnetization (SPA
MM), Manual detection and tracking of tissue tags by visual inspection
remains a time-consuming and tedious process. We have developed an in
teractively guided semi-automated method of detecting and tracking tag
intersections in cardiac MR images, A template matching approach comb
ined with a novel adaptation of active contour modeling permits rapid
analysis of MR images. We have validated our technique using MR SPAMM
images of a silicone gel phantom with controlled deformations. Average
discrepancy between theoretically predicted and semi-automatically se
lected tag intersections was 0.30 mm +/- 0.17 [mean +/- SD, NS (P < 0.
05)]. Cardiac SPAMM images of normal volunteers and diseased patients
also have been evaluated using our technique.