PHOSPHORYLATION OF CALDESMON BY MITOGEN-ACTIVATED PROTEIN-KINASE WITHNO EFFECT ON CA2-MUSCLE( SENSITIVITY IN RABBIT SMOOTH)

Authors
NIXON GF IIZUKA K HAYSTEAD CMM HAYSTEAD TAJ SOMLYO AP SOMLYO AV
Citation
Gf. Nixon et al., PHOSPHORYLATION OF CALDESMON BY MITOGEN-ACTIVATED PROTEIN-KINASE WITHNO EFFECT ON CA2-MUSCLE( SENSITIVITY IN RABBIT SMOOTH), Journal of physiology, 487(2), 1995, pp. 283-289
Citations number
20
Categorie Soggetti
Physiology
Journal title
Journal of physiology → ACNP
ISSN journal
00223751
Volume
487
Issue
2
Year of publication
1995
Pages
283 - 289
Database
ISI
SICI code
0022-3751(1995)487:2<283:POCBMP>2.0.ZU;2-B
Abstract
1. Recombinant, activated mitogen-activated protein kinase (3.3 mu M; p42(mapk)) phosphorylated caldesmon in phasic (rabbit portal vein) and tonic (rabbit femoral artery) smooth muscle strips permeabilized with Triton X-100. 2. Phosphorylation of caldesmon by p42(mapk) neither in duced contraction of relaxed smooth muscle nor affected the Ca2+ sensi tivity of submaximally contracted permeabilized phasic or tonic smooth muscle.