GYNANDROBLASTOMA OF THE OVARY - A CASE-REPORT WITH AN IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL-STUDY

An ovarian gynandroblastoma in a 60-year-old woman is described. The c ut-surface of the right ovary showed multiple macrofollicles separated by white fibrous tissues and multiple ill-defined yellowish nodules. The tumour consisted of substantial amount of a granulosa cell element and a Sertoli cell element with intermingled Leydig cells. Immunohist ochemically, the tumour cells in both the granulosa cell and Sertoli c ell elements were positive for cytokeratin CAM5.2. The granulosa cell element showed strong membrane staining of Ewing's sarcoma antigen 013 and the Sertoli cell element was focally positive. Vimentin was obser ved in both the Sertoli cell element and the granulosa cells. Both ele ments and the Leydig cells were uniformly negative for epithelial memb rane antigen, muscle specific actin, CD31 and CD34. The tumour was ane uploid by flow cytometry. The patient was well with no evidence of tum our five months after surgery.