MICRODIALYSIS SAMPLING AND MICROBORE LIQU ID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION FOR DETERMINATION OF SEROTONIN IN RAT-BRAIN STRIATUM

Authors
XIE FM HUANG TH KISSINGER PT
Citation
Fm. Xie et al., MICRODIALYSIS SAMPLING AND MICROBORE LIQU ID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION FOR DETERMINATION OF SEROTONIN IN RAT-BRAIN STRIATUM, Zhongguo yaoli xuebao, 16(5), 1995, pp. 473-477
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Zhongguo yaoli xuebao → ACNP
ISSN journal
02539756
Volume
16
Issue
5
Year of publication
1995
Pages
473 - 477
Database
ISI
SICI code
0253-9756(1995)16:5<473:MSAMLI>2.0.ZU;2-9
Abstract
AIM: To develop a sensitive method for determination of serotonin in b iological samples. METHODS: A combination of microdialysis sampling an d microbore liquid chromatography with electrochemical detection (LCEC ) established. RESULTS: Changes of serotonin in fg or pg in microdialy sates from brain striatum of the free moving rat were easily determine d. CONCLUSION: This developed method was useful for living animal rese arch. Serotonin level in corpus striatum healthy rats was quite stable .