We study the experimental design problem of selecting a most informati
ve subset, having prespecified size, from a set of correlated random v
ariables. The problem arises in many applied domains, such as meteorol
ogy, environmental statistics, and statistical geology. In these appli
cations, observations can be collected at different locations, and pos
sibly, at different times. Information is measured by ''entropy.'' In
the Gaussian case, the problem is recast as that of maximizing the det
erminant of the covariance matrix of the chosen subset. We demonstrate
that this problem is NP-hard. We establish an upper bound for the ent
ropy, based on the eigenvalue interlacing property, and we incorporate
this bound in a branch-and-bound algorithm for the exact solution of
the problem. We present computational results for estimated covariance
matrices that correspond to sets of environmental monitoring stations
in the United States.