A. Jacquet et al., STUDY OF A NEW PH 5.2-ASTERISK LACTOSERUM LACTIC-ACID EMULSION FOR FEMININE HYGIENE - RESULTS OF A CLINICAL-STUDY, Contraception fertilite sexualite, 23(7-8), 1995, pp. 457-459
A new solution intended for use in feminine hygiene and composed of a
lactic acid base and of lactoserum at pH 5.2, was tested for a period
of 8 weeks on 40 women. This test focused on its influence on the pH a
nd the flora, as well as on the tolerance of the mucous membrane. Succ
essive measurements of the vulvar and vaginal pH revealed no statistic
ally significant variation between the beginning and the end of the tr
ial. At the study inclusion thirty patients had a normal flora; of the
se, twenty-eight showed no change during the eight weeks of the trial.
A candidiasis appeared in two patients in the middle of the trial; on
e of these patients received no treatment, while the other was given a
five-day treatment due to similar occurrences in her past medical his
tory. The product under study was continued throughout the trial, at t
he conclusion of which the flora was found to have returned to normal.
At the study inclusion ten patients had either a candidiasis or a vag
initis. Their lack of symptoms and the absence of any previous problem
s resulted in no treatment being made in five of the ten cases, while
in four cases the presence of such prior problems led to the immediate
carrying out of short-length treatments. In every case, the product u
nder study was used until the end of the trial. Bacteriological studie
s showed that in all the patients - whether or not they had been treat
ed - the flora rapidly returned to normal. One patient, who had a vulv
al pruritus at the study inclusion, received a treatment only at the s
tage of the intermediate visit. This patient showed no improvement by
the end of the test, fully recovered following the trial, then suffere
d a relapse when the product had not been used for seven weeks. This s
tudy demonstrates the excellent cutaneous-mucous tolerance of this sli
ghtly acid solution, as is proven by the excellent compliance as well
as by its respect of vulvovaginal flora.