A total of 33 patients presenting with various cerebral lesions were o
perated on with stereotactic guided craniotomy. In all cases the lesio
n could be totally removed and only one patient suffered from a recurr
ent metastasis. The survival time of patients with malignant brain tum
ors was in the range of the generally reported data. All the six patie
nts with malignant gliomas developed a recurrence, four of them have s
ince died. Three of the four patients with brain metastases died from
systemic progression of their disease, and one patient died from a rec
urrence of a centrally located metastasis. A new neurological deficit
occurred in only two patients. Despite the often deep or central local
ization of the lesions, major complications were rare. Stereotactic gu
idance and preoperative selection of the entry point allow a safer sur
gical procedure, a larger indication for open surgery in cases conside
red as not removable, and reduce surgical morbidity.