INTEGRAL PHOTODYNAMIC TREATMENT OF REFRACTORY SUPERFICIAL BLADDER-CANCER

Purpose: Cystectomy is indicated after unsuccessful transurethral rese ction and intravesical treatment of superficial bladder cancer. As an alternative, whole bladder photodynamic therapy was done. Materials an d Methods: In 21 patients the bladder was irradiated with laser light at a wavelength of 630 nm, after intravenous injection of a synthetic porphyrin mixture. Results: Of the 21 patients 12 attained complete re mission with a mean disease-free interval of 18.0 months (range 3 to 4 2), 3 with partial remission were rendered disease-free with transuret hral resection or neodymium:YAG laser coagulation and 6 underwent cyst ectomy. Conclusions: In patients with refractory superficial bladder c ancer the bladder can be preserved by use of photodynamic therapy.