HISTOPATHOLOGICAL FEATURES AND P53 NUCLEAR-PROTEIN STAINING AS PREDICTORS OF SURVIVAL AND TUMOR RECURRENCE IN PATIENTS WITH TRANSITIONAL-CELL CARCINOMA OF THE RENAL PELVIS

Purpose: We determine which histopathological features are predictive of recurrence and cause-specific survival in renal pelvic transitional cell carcinoma.Materials and Methods: Univariant and multivariant ana lysis was done on material from 67 patients. Results: Univariate and m ultivariate analysis identified lamina propria invasion, grade 3 turne rs and capillary-lymphatic invasion as predictors of disease-specific survival Multicentric disease was the sole independent predictor of re currence. Multicentric disease and lamina propria invasion were indepe ndent predictors of recurrence-free survival. Also, p53 over-expressio n was not-statistically associated with any of the studied prognostic factors. Conclusions: Histopathological features remain the cornerston e of prognostic assessment for renal pelvic transitional cell carcinom a.