Purpose: We investigated a possible bacterial etiology for prostatodyn
ia. Materials and Methods: We evaluated segmented urine specimens from
22 patients and 16 controls by bacteriological localization studies.
Immunological studies were performed on patient and control sera. Resu
lts: Nine patients had positive cultures from prostatic secretions; Wh
en compared to controls, this novel finding was statistically signific
ant (p <0.025). Coagulase-negative staphylococci were the most common
isolates (68%). No humoral (IgG) immune differences were found between
patients and controls. Conclusions: In a subset of prostatodynia pati
ents bacteria may have an etiological role. Antibiotic treatment demon
strated clinical efficacy.