Operation at sufficiently high gain (ratio of fusion power to external
heating power) is a fundamental requirement for tokamak power reactor
s. For typical reactor concepts, the gain is greater than 25. Self-hea
ting from alpha particles in deuterium-tritium plasmas can greatly red
uce n tau/temperature requirements for high gain. A range of high gain
operating conditions is possible with different values of alpha-parti
cle efficiency (fraction of alpha-particle power that actually heats t
he plasma) and with different ratios of self heating to external heati
ng. At one extreme, there is ignited operation, where all of the requi
red plasma heating is provided by alpha particles and the alpha-partic
le efficiency is 100%. At the other extreme, there is the case of no h
eating contribution from alpha particles. n tau/temperature requiremen
ts for high gain are determined as a function of alpha-particle heatin
g efficiency. Possibilities for high gain experiments in deuterium-tri
tium, deuterium, and hydrogen plasmas are discussed.