MOUSE COL18A1 IS EXPRESSED IN A TISSUE-SPECIFIC MANNER AS 3 ALTERNATIVE VARIANTS AND IS LOCALIZED IN BASEMENT-MEMBRANE ZONES

Authors
MURAGAKI Y TIMMONS S GRIFFITH CM OH SP FADEL B QUERTERMOUS T OLSEN BR
Citation
Y. Muragaki et al., MOUSE COL18A1 IS EXPRESSED IN A TISSUE-SPECIFIC MANNER AS 3 ALTERNATIVE VARIANTS AND IS LOCALIZED IN BASEMENT-MEMBRANE ZONES, Proceedings of the National Academy of Sciences of the United Statesof America, 92(19), 1995, pp. 8763-8767
Citations number
24
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
92
Issue
19
Year of publication
1995
Pages
8763 - 8767
Database
ISI
SICI code
0027-8424(1995)92:19<8763:MCIEIA>2.0.ZU;2-8
Abstract
We have isolated overlapping cDNAs encoding the N-terminal non-triple- helical region of mouse alpha 1(XVIII) collagen and shown that three d ifferent variants of alpha 1(XVIII) collagen exist. Each of the three variants shows characteristic tissue-specific expression, patterns. Im munohistochemical studies show positive staining for alpha 1(XVIII) co llagen along the basement membrane zones of vessels in the intestinal villi, the choroid plexus, skin, liver, and kidney. Thus, we conclude that alpha 1(XVIII) collagen may interact (directly or indirectly) wit h components in basement membrane zones or on the basal surface of end othelial/epithelial cells.