EVALUATION OF NEUROMUSCULAR EFFECTS AND ANTAGONISM OF ROCURONIUM BROMIDE - A PRELIMINARY-REPORT

Twenty ASA I-II patients received either 2 or 3 x ED(95) doses of rocu ronium bromide during nitrous oxide, oxygen, propofol, fentanyl-based anaesthesia. The mean times to maximum block were 98 s and 74 s and th e mean duration of clinical relaxation (recovery to 25% T1) was 35 min and 46 min following 620 mu g kg(-1) and 930 mu g kg(-1), respectivel y. Neuromuscular blockade was antagonized with either neostigmine or e drophonium from a twitch height of 25%. Although there was no signific ant difference between the recovery times neostigmine appeared to give more consistent antagonism of rocuronium-induced blockade.