M. Korabiowska et al., DIFFERENCES OF PLOIDY STATUS IN PROGRESSION OF HEAD AND NECK MELANOMAS, International journal of oncology, 10(2), 1997, pp. 381-385
Thirty-three common naevi, 26 dysplastic naevi, 58 primary melanomas o
f facial skin, 24 oral melanomas, 32 lymph nodes and 12 distant melano
ma metastases were stained using Feulgen method to evaluate the ploidy
status by image analysis GAS-200 system. Eight percent of common naev
i, 22% of dysplastic naevi, 43% of facial melanomas, 65% of oral melan
omas, 40% of lymph nodes with melanoma metastases and 66% of distant m
elanoma metastases were classified as aneuploid. In facial melanomas t
he percentage of aneuploid cases increased with Clark level. Survival
time of patients was significantly shorter for aneuploid cases as comp
ared to euploid ones (p <0.01).