BINDING MODE OF DISTAMYCIN TO D(CGTACGTACG)(2) IN THE 2 1 SOLUTION COMPLEX AS DETERMINED BY 2-DIMENSIONAL H-1-NMR AND MOLECULAR MODELING STUDIES/

Authors
GARBESI A TONDELLI L CONTE MR GALEONE A PALOMA LG MAYOL L
Citation
A. Garbesi et al., BINDING MODE OF DISTAMYCIN TO D(CGTACGTACG)(2) IN THE 2 1 SOLUTION COMPLEX AS DETERMINED BY 2-DIMENSIONAL H-1-NMR AND MOLECULAR MODELING STUDIES/, Gazzetta chimica italiana, 126(12), 1996, pp. 799-804
Citations number
28
Categorie Soggetti
Chemistry
Journal title
Gazzetta chimica italiana → ACNP
ISSN journal
00165603
Volume
126
Issue
12
Year of publication
1996
Pages
799 - 804
Database
ISI
SICI code
0016-5603(1996)126:12<799:BMODTD>2.0.ZU;2-J
Abstract
Previous UV and CD studies indicated a high affinity of d(CGTACGTACG)( 2), 1, for distamycin, 2, though it does not possess the commonly acce pted site for this ligand. The binding mode of the drug has now been i nvestigated by a combination of high-resolution H-1 NMR and molecular modelling. The structure of the complex contains two molecules of drug symmetrically placed at the centre along the strands of DNA, spanning the minor groove with the first two pyrrole rings of one molecule in close contact with those of the other one.